TDNet Discover

Background: Fractional ablative laser treatment has been widely accepted as the best treatment for atrophic acne scars. New research suggests that the addition of platelet-rich plasma (PRP) to fractional ablative laser therapy may provide superior results in terms of scar reduction. Objective: The aim of this evidence-based medicine literature review is to determine whether a combination of platelet-rich plasma and fractional ablative laser resurfacing or fractional ablative laser therapy alone is more effective in the treatment and reduction of atrophic acne scars in adults. Methods: Online databases including PubMed, UpToDate, Google Scholar, and Discover @ South College were searched using search terms “platelet rich plasma AND dermatology AND scar,” “prp AND scar AND laser,” “‘platelet-rich plasma’ AND scar and laser.” Three independent researchers searched for and reviewed articles that met inclusion and exclusion criteria, as well as deemed a high level of evidence. Once final articles were selected, they were assessed for quality and qualitatively analyzed. Results: Dual PRP and fractional ablative laser resurfacing and fractional ablative laser resurfacing alone, both significantly reduced the appearance of atrophic acne scars. Dual therapy may reduce acne scars to a greater degree than fractional ablative laser therapy alone, as well as decrease the severity and duration of adverse effects. Conclusion: PRP combined with fractional ablative laser therapy has the potential to improve acne scars and reduce adverse effects compared to fractional ablative laser therapy alone;however, additional research is needed to establish guidelines for the use of dual therapy in acne scar reduction.