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Perioperative pain management utilizing opioids contributes to the opioid epidemic that has ravaged the United States causing a rise in death rates and a national financial burden. While multiple risk factors are responsible for the opioid use disorder, lack of universal guidelines and overtreatment play a major role;therefore, evaluation of alternative pain medications in order to find an efficient approach to avoid opioid use disorder is a necessity. The objective of this systematic review is to determine the most effective treatment method to prevent the development of opioid use disorder in postoperative patients. A comprehensive literature search using the databases of PubMed, EBSCOhost, and ProQuest resulted in 72 articles retrieved. By a critical evaluation, the articles were narrowed down using inclusion and exclusion criteria to 11 articles to be included in the final study. Different perioperative multimodal pain management plans were evaluated in order to reduce postoperative opioid use. Thorough analysis of each article resulted in statistically significant improvements in postoperative opioid use and development of opioid use disorder by utilizing alternative analgesics, minimizing preoperative opioid consumption, and implementing opioid prescription guidelines. While results show there are multiple effective alternative analgesic methods that may reduce or eliminate the need for postoperative opioid use, the best method is determined on an individual level. Future research should focus on individualized protocols regarding alternative analgesics for each specific type of surgery as well as aim to identify risks for developing opioid use disorder. Overall, effective use of alternative analgesics shows a promising outlook regarding opioid use disorder and the opioid epidemic as a whole.